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KMID : 0606920150230020165
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Biomolecules & Therapeutics
2015 Volume.23 No. 2 p.165 ~ p.173
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Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
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Hewage Susara Ruwan Kumara Madduma
Piao Mei Jing
Kim Ki-Cheon
Cha Ji-Won
Han Xia
Choi Yung-Hyun
Chae Sung-Wook
Hyun Jin-Won
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Abstract
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Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
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KEYWORD
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Apoptosis, Galangin, Human keratinocytes, Oxidative damage, Ultraviolet B
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